Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells...
Many antidepressants are cationic amphipaths, which spontaneously accumulate in natural or reconstituted membranes in the absence of their specific protein targets. However, the clinical relevance of...
View ArticleThe Antidepressant Sertraline Targets Intracellular Vesiculogenic Membranes...
This is our prevous paper on sertraline’s (Zoloft) effects on yeast cells. Published in Genetics May, 2010.
View ArticleHexagonal and multilamellar phospholipid phases
An autophagosome containing a multilamellar body from a representative wildtype yeast cell treated for three minutes with the SSRI antidepressant sertraline/Zoloft (60µM). Zooms of the multilamellar...
View ArticleWhat’s going on with this lipid droplet?
We observe diversity of lipid droplet morphology in yeast cells treated with the SSRI antidepressant sertraline/Zoloft, including lipid droplet fusion, fisson and assimllation into organelles involved...
View ArticleDrug accumulation thickens cell membrane
An image gallery of wildtype BY4716 yeast cells treated with 25µM amiodarone for 45 minutes. Amiodarone, a cationic amphipath (fat-soluble weak base), is known to cause phospholipidosis in lab animals...
View ArticleThe vacuole life cycle of yeast series, cell #4
Transmission electron microscopy is a powerful technique that allows us to peer deep inside cells. Dynamic cellular processes, like the fission and fusion of internal compartments, are frozen in time...
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